Session Description

Nucleic acids including DNA and RNA contain over 150 noncanonical nucleosides. Among these epigenetically modified nucleosides, many are sensitive to conditions used by the existing DNA/RNA synthesis technologies. Therefore, nucleic acids containing sensitive modified nucleosides are currently inaccessible via synthetic chemistry or highly challenging.

In this presentation, Dr. Shiyue Fang will showcase experimental examples of sensitive nucleosides, including their biological roles and relationships to clinical applications, challenges related to nucleic acids synthesis containing sensitive nucleosides, and the current status of the Dim-Dmoc method developed by his research group at the Michigan Technological University that overcomes related obstacles. In addition, Dr. Fang will also share personal opinions regarding the potential applications of sensitive nucleic acids accessible by the Dim-Dmoc method.

Highlights of the presentation

Diverse structures of sensitive nucleosides

Insights on applications of sensitive nucleic acids

Dim-Dmoc methods for sensitive nucleic acid synthesis